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Safety (cardiac & more)

How does ibogaine kill — and how do we prevent it?

49 papers

2020s · 12

BruntRare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias
Addiction·2026·Review
Esperança et al.Ibogaine: Therapeutic Potential, Cardiac Safety, and Translational Perspectives in the Treatment of Substance Use Disorders—A Scoping Review
Molecules·2026·Review
EvansLearning from ibogaine fatalities, rather than covering them up
Ecstatic Integration (Substack)·2026·Journalism
Edwards et al.A case series of ibogaine toxicity reported to the United Kingdom National Poisons Information Service (NPIS) over a 10-year period
Clinical Toxicology·2025·Case series
ChenRisk Assessment of Herbal Preparations Containing Tabernanthe iboga
2024·Review
Mestre et al.Multiple Episodes of Cardiac Arrest Induced by Treatment With Ibogaine: A Case Report
Cureus·2024·Case report
Vidonja Uzelac et al.Ibogaine Induces Cardiotoxic Necrosis in Rats—The Role of Redox Processes
International Journal of Molecular Sciences·2024·Preclinical
BusbyHe Took a Psychedelic to Cure His Addiction. It Was His Last Trip
Rolling Stone·2024·Journalism
Aćimović et al.Death due to consumption of ibogaine: case report
Forensic Science, Medicine, and Pathology·2021·Case report
Knuijver et al.Safety of ibogaine administration in detoxification of opioid-dependent individuals: a descriptive open-label observational study
Addiction·2021·Case series
Ona et al.The adverse events of ibogaine in humans: an updated systematic review of the literature (2015–2020)
Psychopharmacology·2021·Syst. review
Shi et al.A New Approach Methodology (NAM) for the Prediction of (Nor)Ibogaine-Induced Cardiotoxicity in Humans
ALTEX - Alternatives to Animal Experimentation·2021·In vitro

2010s · 31

Grogan et al.Ibogaine Consumption with Seizure-Like Episodes, QTc-Prolongation, and Captured Cardiac Dysrhythmias
The Journal of Emergency Medicine·2019·Case report
CorkeryIbogaine as a Treatment for Substance Misuse: Potential Benefits and Practical Dangers
Progress in Brain Research·2018·Review
Steinberg et al.Cardiac arrest after ibogaine intoxication
Journal of Arrhythmia·2018·Case report
AlbertIbogaine Related Fatalities: Compilation of Public Domain Case Reports 1990–2010
2018·Case series
Henstra et al.Toxicokinetics of ibogaine and noribogaine in a patient with prolonged multiple cardiac arrhythmias after ingestion of internet purchased ibogaine
Clinical Toxicology·2017·Case report
Rubi et al.Anti-addiction Drug Ibogaine Prolongs the Action Potential in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular Toxicology·2017·In vitro
S v Jeewa (KZN High CourtMartinovic Death at Minds Alive Wellness Centre, Durban (November 2017): Court Record
2017·Primary source
Alper et al.hERG Blockade by Iboga Alkaloids
Cardiovascular Toxicology·2016·In vitro
Glue et al.Ascending Single-Dose, Double-Blind, Placebo-Controlled Safety Study of Noribogaine in Opioid-Dependent Patients
Clinical Pharmacology in Drug Development·2016·RCT
Litjens et al.How toxic is ibogaine?
Clinical Toxicology·2016·Review
Meisner et al.Ibogaine-associated cardiac arrest and death: case report and review of the literature
Therapeutic Advances in Psychopharmacology·2016·Case report
Schep et al.Ibogaine for treating drug dependence. What is a safe dose?
Drug and Alcohol Dependence·2016·Review
Breuer et al."Herbal seizures" – atypical symptoms after ibogaine intoxication: a case report
Journal of Medical Case Reports·2015·Case report
Hildyard et al.A Case of QT Prolongation and Torsades de Pointes Caused by Ibogaine Toxicity
The Journal of Emergency Medicine·2015·Case report
Koenig et al.The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation
Molecules·2015·Review
Marta et al.Mania following use of ibogaine: A case series
American Journal on Addictions·2015·Case series
O'Connell et al.Internet-purchased ibogaine toxicity confirmed with serum, urine, and product content levels
American Journal of Emergency Medicine·2015·Case report
Thurner et al.Mechanism of hERG Channel Block by the Psychoactive Indole Alkaloid Ibogaine
Journal of Pharmacology and Experimental Therapeutics·2014·In vitro
Vlaanderen et al.Cardiac Arrest After Ibogaine Ingestion
Clinical Toxicology·2014·Case report
AsuaGrowing Menace of Ibogaine Toxicity
British Journal of Anaesthesia·2013·Case report
Jalal et al.A Case of Death Due to Ibogaine Use for Heroin Addiction
The American Journal on Addictions·2013·Case report
Koenig et al.Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile
Toxicology and Applied Pharmacology·2013·In vitro
Mazoyer et al.Fatal Case of a 27-Year-Old Male After Taking Iboga in Withdrawal Treatment: GC-MS/MS Determination of Ibogaine and Ibogamine in Iboga Roots and Postmortem Biological Material
Journal of Forensic Sciences·2013·Case report
Papadodima et al.Ibogaine related sudden death: A case report
Journal of Forensic and Legal Medicine·2013·Case report
Alper et al.Fatalities Temporally Associated with the Ingestion of Ibogaine
Journal of Forensic Sciences·2012·Syst. review
BoozeIbogaine
ToxTidbits (Maryland Poison Center)·2012·Review
Koenig et al.Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk
Addiction Biology·2012·In vitro
Paling et al.Life-threatening complications of ibogaine: three case reports
The Netherlands Journal of Medicine·2012·Case report
Pleskovic et al.Ibogaine-associated ventricular tachyarrhythmias
Clinical Toxicology·2012·Case report
Shawn et al.Pause-dependent ventricular tachycardia and torsades de pointes after ibogaine ingestion
Clinical Toxicology·2012·Case report
Warrick et al.Ibogaine for opioid addiction: A Deadly treatment
Clinical Toxicology·2012·Case report

2000s · 5

Hoelen et al.Long-QT Syndrome Induced by the Antiaddiction Drug Ibogaine
New England Journal of Medicine·2009·Case report
Chèze et al.Determination of ibogaine and noribogaine in biological fluids and hair by LC–MS/MS after Tabernanthe iboga abuse: Iboga alkaloids distribution in a drowning death case
Forensic Science International·2008·Case report
Kontrimavičiūtė et al.Distribution of Ibogaine and Noribogaine in a Man Following a Poisoning Involving Root Bark of the Tabernanthe iboga Shrub
Journal of Analytical Toxicology·2006·Case report
Maas et al.Fatalities after taking ibogaine in addiction treatment could be related to sudden cardiac death caused by autonomic dysfunction
Medical Hypotheses·2006·Commentary
Marker et al.Ibogaine Related Fatality
Annales de Toxicologie Analytique·2002·Case report

Pre-1990 · 1

DhahirA Comparative Study on the Toxicity of Ibogaine and Serotonin
1971·Preclinical