Ibogaine Induces Cardiotoxic Necrosis in Rats—The Role of Redox Processes

Vidonja Uzelac, Teodora, Tatalović, Nikola, Mijović, Milica, Miler, Marko, Grahovac, Tanja, Oreščanin Dušić, Zorana, Nikolić-Kokić, Aleksandra, Blagojević, Duško · 2024 · International Journal of Molecular Sciences

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First histopathological demonstration of dose-dependent myocardial necrosis in rats from oral ibogaine. Low dose (1mg/kg): focal. High dose (20mg/kg): diffuse extensive (>51% per paper's scoring). Non-inflammatory mechanism.

Dosing: 1 or 20 mg/kg b.w. single dose per os by gavage (oral)