Toxicokinetics of ibogaine and noribogaine in a patient with prolonged multiple cardiac arrhythmias after ingestion of internet purchased ibogaine

Henstra, Marieke, Wong, Liza, Chahbouni, Abdel, Swart, Noortje, Allaart, Cor, Sombogaard, Ferdi · 2017 · Clinical Toxicology

AI-extracted · unverified · confirm at source

Ibogaine causes acute cardiac toxicity (QTc 647ms, TdP at peak); noribogaine sustains it — QTc >450ms at days 5+11 after ibogaine clearance. t½ 2285h (ibogaine), 2540h (noribogaine). k₁₂/k₂₁ ratio 21.5 implies deep tissue sequestration.

Dosing: 1400 mg oral (repeated doses over 12 hours, internet-sourced capsules) (oral)

Sample size: 1

Safety data present: QTC, ELECTROLYTE

Contraindications: Pre-existing cardiac conditions, Concurrent CYP2D6-metabolised medications, Electrolyte imbalances (hypokalaemia, hypomagnesaemia)