Ibogaine for treating drug dependence. What is a safe dose?

Schep, Leo J., Slaughter, Robin J., Galea, Sawitri, Newcombe, David · 2016 · Drug and Alcohol Dependence

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Dual-route dose calculation (IP NOAEL 0.83, oral LD50 0.87 mg/kg) converges sub-1 mg/kg; critiques Mash et al. (1998) applying IP NOAEL to oral dosing; hERG IC50 overlaps therapeutic concentrations; recommends <1 mg/kg limit and dosing moratorium

Dosing: 0.87 mg/kg theoretical safe oral dose; clinical use 6–30 mg/kg oral (oral)

Safety data present: QTC, HERG, ELECTROLYTE

Contraindications: Pre-existing cardiac conditions, CYP2D6 poor metaboliser status, Chronic sympathomimetic use (cocaine, methamphetamine), Medical comorbidities associated with long-term drug use