A Comparative Study on the Toxicity of Ibogaine and Serotonin
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Ibogaine LD50 145 mg/kg rat i.p.; tissue peaks liver/kidney 1h, cleared 12h; 15% excreted as indolic metabolite (not 5-HIAA); vagal hypotension/bradycardia (atropine-reversible); ethanol 2g/kg potentiates 1.4x; iproniazid enhances acute toxicity.
Dosing: Acute (rat i.p.): 110–189 mg/kg administered; LD50 145 mg/kg. Acute (mouse i.p.): up to 216 mg/kg; LD50 175 mg/kg. Acute (rat i.g.): up to 448 mg/kg; LD50 327 mg/kg. Chronic: 10 + 50 mg/kg/d × 30 d (n=4/group); 40 mg/kg/d × 12 d. Cardiovascular: 2, 4, 8, 16, 32 mg/kg i.v. (intraperitoneal)
Contraindications: Ethanol (high dose) — 2 g/kg potentiates ibogaine acute toxicity 1.4x (rat i.p.), MAOIs (iproniazid) — pretreatment significantly enhances ibogaine acute toxicity at <1/2 usual threshold