Pause-dependent ventricular tachycardia and torsades de pointes after ibogaine ingestion

Shawn, Lauren K., Alper, Kenneth, Desai, Shalin P., Stephenson, Kent, Olgun, Aydin M., Nelson, Lewis S., Hoffman, Robert S. · 2012 · Clinical Toxicology

AI-extracted · unverified · confirm at source

First documented case of pause-dependent VT and TdP after ibogaine in a patient with normal pretreatment screening, demonstrating screening limitations.

Dosing: 10.5 mg/kg ibogaine HCl (85–98% purity) + 14 mg/kg T. iboga root bark extract (50% alkaloids) over 15 hours (oral)

Sample size: 1

Safety data present: QTC, ELECTROLYTE

Contraindications: Concurrent or recent methadone use (patient transitioned off one month prior), Aggressive cathartic use prior to ibogaine (caused persistent hypokalemia), Combined ibogaine HCl and root bark extract administration (dual-source dosing), Non-medical setting without continuous cardiac monitoring