hERG Blockade by Iboga Alkaloids

Alper, Kenneth, Bai, Rong, Liu, Nian, Fowler, Steven J., Huang, Xi-Ping, Priori, Silvia G., Ruan, Yanfei · 2016 · Cardiovascular Toxicology

AI-extracted · unverified · confirm at source

LANDMARK hERG DATA: Whole-cell patch clamp IC₅₀ values - ibogaine 4.09μM, noribogaine 2.86μM, voacangine 2.25μM. 18-MC >50μM (12× safer). Noribogaine's extended T½ may explain delayed cardiac events.

Dosing: In-vitro concentrations: 0.1–10,000 nM (radioligand binding); 1–100 μM (patch clamp) (not-applicable)

Safety data present: HERG