Ibogaine-associated ventricular tachyarrhythmias

Pleskovic, Ales, Gorjup, Vojka, Brvar, Miran, Kozelj, Gordana · 2012 · Clinical Toxicology

AI-extracted · unverified · confirm at source

Single 600mg ibogaine dose caused 5 VFs and 3 VTs over 48h with QTc prolongation to 593ms at 42h. Amiodarone worsened QTc. Vagal maneuvers triggered arrhythmias. QTc normalised day 9.

Dosing: 600 mg oral (single dose) (oral)

Sample size: 1

Safety data present: QTC, ELECTROLYTE

Contraindications: QTc-prolonging medications (e.g., amiodarone, methadone), Pre-existing QT prolongation, Recent polysubstance use