A Dose-Response Study of Ibogaine-Induced Neuropathology in the Rat Cerebellum

Xu, Zengjun, Chang, Louis W., Slikker, William Jr., Ali, Syed F., Rountree, Robert L., Scallet, Andrew C. · 2000 · Toxicological Sciences

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Ibogaine ip NOAEL 25 mg/kg in female rats. Purkinje cell degeneration dose-dependent: 0/6 at 25, 2/6 at 50, 6/6 at 75–100 mg/kg. GFAP most sensitive biomarker.

Contraindications: Pre-existing cerebellar pathology