Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity

Sweetnam, P. M., Lancaster, J., Snowman, Adele, Collins, J. L., Perschke, S., Bauer, C., Ferkany, J. · 1995 · Psychopharmacology

AI-extracted · unverified · confirm at source

Ibogaine binds 14 receptors at 1–100 μM: dopamine uptake IC₅₀ 3.5 μM, NMDA/MK-801 5.6 μM, 5-HT₃ 3.9 μM, 5-HT₂ 4.8 μM, κ-opioid 16 μM; no nanomolar affinity at any site.