Pharmacological screen for activities of 12-hydroxyibogamine: a primary metabolite of the indole alkaloid ibogaine

Staley, Julie K., Ouyang, Qinjie, Pablo, John, Hearn, Wayne L., Flynn, Dwight D., Rothman, Richard B., Rice, Kenner C., Mash, Deborah C. · 1996 · Psychopharmacology

AI-extracted · unverified · confirm at source

Noribogaine 10× more potent than ibogaine at SERT (IC₅₀ 40.7 nM vs 590 nM). Both ~equipotent at DAT (~3-4 μM). Brain levels 1-17 μM post-oral dosing; metabolite rises 10-fold over 2h as parent declines.