Ibogaine Reduces Preference for Cocaine Consumption in C57BL/6By Mice

Sershen, Henry, Hashim, Audrey, Lajtha, Abel · 1994 · Pharmacology Biochemistry and Behavior

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Ibogaine (2×40 mg/kg IP) reduced cocaine preference from 71% to 41% and intake by 38% for ≥5 days in C57BL/6By mice. Attenuated cocaine-induced locomotor sensitisation independently of brain cocaine levels.

Dosing: 2×40 mg/kg IP ibogaine HCl (6 h apart); cocaine 200–400 mg/l oral, 25 mg/kg SC challenge (intraperitoneal)