Ibogaine Antagonizes Cocaine-Induced Locomotor Stimulation in Mice
Mechanisms Preclinical moderate
AI-extracted · unverified · confirm at source
Ibogaine (40 mg/kg) reduces cocaine-induced locomotor stimulation in mice for ≥9 days. Selective for cocaine (not amphetamine). Transiently increases DA turnover (DOPAC+HVA/DA). Weak DAT affinity (IC₅₀ 1500 nM vs cocaine 120 nM).