Treating drug dependence with the aid of ibogaine: A retrospective study

Schenberg, Eduardo Ekman, de Castro Comis, Maria Angélica, Rasmussen Chaves, Bruno, da Silveira, Dartiu Xavier · 2014 · Journal of Psychopharmacology

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Brazilian retrospective (n=75, 134 sessions): 61% abstinent, median 5.5mo (single) vs 8.4mo (multiple tx, p<0.001). Zero serious AEs or fatalities. First systematic non-opioid dependence data.

Dosing: 7.5–20 mg/kg ibogaine HCl (typical 17 mg/kg) (oral)

Sample size: 75

Contraindications: Pregnancy, Surgery within 6 months, Uncontrolled hypertension, Uncontrolled diabetes, Cardiac arrhythmias, Renal insufficiency, Hepatic insufficiency, Alzheimer's disease, Parkinson's disease, Psychiatric comorbidities, Active substance use (30–60 day abstinence period required prior to administration)