Ibogaine Produces Neurodegeneration in Rat, but Not Mouse, Cerebellum: Neurohistological Biomarkers of Purkinje Cell Loss

Scallet, A. C., Ye, X., Rountree, R., Nony, P., Ali, S. F. · 1996 · Annals of the New York Academy of Sciences

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Ibogaine 100 mg/kg i.p. causes parasagittal Purkinje cell degeneration in rat cerebellum (silver stain, calbindin loss, GFAP astrocytosis) but no neurotoxicity in mice at same dose. H&E staining insufficient—risks false negatives.