A Single Administration of the Atypical Psychedelic Ibogaine or its Metabolite Noribogaine Induces an Antidepressant-like Effect in Rats

Rodríguez, Paola, Urbanavicius, Jessika, Prieto, José Pedro, Fabius, Sara, Reyes, Ana Laura, Havel, Vaclav, Sames, Dalibor, Scorza, Cecilia, Carrera, Ignacio · 2020 · ACS Chemical Neuroscience

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Single ibogaine or noribogaine dose produces antidepressant-like effect in rat FST; both compounds required simultaneously in brain, suggesting polypharmacological mechanism beyond SERT inhibition

Dosing: 20 and 40 mg/kg IP (ibogaine HCl and noribogaine HCl); 1 and 5 mg/kg IV (ibogaine HCl) (intraperitoneal)