Attenuation of Alcohol Intake by Ibogaine in Three Strains of Alcohol-Preferring Rats

Rezvani, Amir H., Overstreet, David H., Lee, Yue-Wei · 1995 · Pharmacology Biochemistry and Behavior

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Ibogaine IP/IG (not SC) dose-dependently reduced alcohol intake in P, FH, AA rats; 60 mg/kg IP: 51–65% reduction; 5-day IG dosing showed no tolerance; no effect on blood alcohol; suggests hepatic metabolic activation required