Neuropharmacological characterization of local ibogaine effects on dopamine release

Reid, M. S., Hsu, K. Jr., Souza, K. H., Broderick, P. A., Berger, S. P. · 1996 · Journal of Neural Transmission

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BIPHASIC MECHANISM: Local ibogaine shows dose-dependent dual effects - low doses (10⁻⁶-10⁻⁴M) decrease dopamine via kappa receptors, high doses (10⁻³M) increase dopamine via DAT interaction.

Dosing: 10⁻⁶M-10⁻³M (local perfusion, rat)