Ibogaine Effect on Cocaine Craving and Use in Dependent Patients - A Double-Blind, Placebo-Controlled Pilot Study
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Single 1800mg ibogaine dose significantly reduced cocaine craving (MCCS 7.4→1.3 at 72h, p<0.0001) and positive urine samples vs placebo over 24 weeks in N=20 RCT.
Dosing: 1800 mg single dose (dried ibogaine extract, 75% purity, encapsulated with excipients) (oral)
Sample size: 20
Contraindications: Current alcohol or other drug dependence (other than nicotine), Significant cardiovascular conditions or current cardiac condition, Renal disorders, Endocrine disorders, Hepatic disorders (SGOT or SGPT >3× normal), Hypotension or hypertension, Seizure disorder, Lifetime diagnosis of schizophrenia, bipolar disorder, or other psychotic disorders, Active suicidality or homicidality, Current prescription for psychotropic medication