The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex
Mechanisms In vitro moderate
AI-extracted · unverified · confirm at source
Ibogaine competitively inhibits [³H]MK-801 binding at NMDA receptor ion channels (Kᵢ = 1.01 ± 0.1 μM, nH = 1.2). No effect on AMPA, kainate, or metabotropic glutamate receptors up to 100 μM.