Metabolic plasticity and the energy economizing effect of ibogaine, the principal alkaloid of Tabernanthe iboga

Paškulin, Roman, Jamnik, Polona, Danevčič, Tjaša, Koželj, Gordana, Krašovec, Rok, Krstić-Milošević, Dijana, Blagojević, Duško, Štrukelj, Borut · 2012 · Journal of Ethnopharmacology

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Ibogaine triggers dose-dependent biphasic CO₂ elevation in yeast (peak +142% at 20 mg/l), reduces oxidative load 24–57% via pro-antioxidant mechanism, and establishes lower-energy metabolic equilibrium.

Dosing: 1–20 mg/l in yeast culture (not-applicable)