Induction of energy metabolism related enzymes in yeast Saccharomyces cerevisiae exposed to ibogaine is adaptation to acute decrease in ATP energy pool

Paškulin, Roman, Jamnik, Polona, Obermajer, Nataša, Slavić, Marija, Štrukelj, Borut · 2010 · European Journal of Pharmacology

AI-extracted · unverified · confirm at source

MECHANISM CONFIRMATION: Yeast model shows ibogaine causes acute ATP decrease triggering compensatory enzyme induction. Supports energy metabolism hypothesis - neuroplasticity may require enhanced metabolic capacity.

Dosing: 1–20 mg/l (≈3–64 µM) in yeast culture (not-specified)