Ibogaine affects brain energy metabolism

Paškulin, Roman, Jamnik, Polona, Živin, Marko, Raspor, Peter, Štrukelj, Borut · 2006 · European Journal of Pharmacology

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NOVEL MECHANISM: Ibogaine induces glycolysis/TCA cycle enzymes (GAPDH, aldolase A, pyruvate kinase, malate dehydrogenase) at 24-72h. Anti-addiction effect may be mediated by enhanced energy availability for neuroplasticity.

Dosing: 20 mg/kg i.p. (rats) (intraperitoneal)