Degeneration of Purkinje Cells in Parasagittal Zones of the Cerebellar Vermis after Treatment with Ibogaine or Harmaline
Mechanisms Preclinical moderate
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Ibogaine (100 mg/kg) and harmaline cause selective Purkinje cell degeneration in parasagittal zones of rat cerebellar vermis via proposed olivocerebellar excitotoxic mechanism. Doses 4× proposed human dose.
Dosing: 100 mg/kg (single dose, daily × 3, or two doses 8 h apart) (intraperitoneal)