Acute and Chronic Administration of Ibogaine to the Rat Results in Astrogliosis That Is Not Confined to the Cerebellar Vermis

O'Callaghan, James P., Rogers, Tina S., Rodman, Larry E., Page, John G. · 1996 · Annals of the New York Academy of Sciences

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Ibogaine causes dose-, sex-, region-dependent astrogliosis in rats. Chronic oral dosing: up to 215% GFAP increases in female hippocampus, brain stem, striatum; males unaffected. NF-68/beta-tubulin >2-fold in females. Gliosis beyond cerebellar vermis.