Cytochrome P4502D6 Catalyzes the O-Demethylation of the Psychoactive Alkaloid Ibogaine to 12-Hydroxyibogamine

Obach, R. Scott, Pablo, John, Mash, Deborah C. · 1998 · Drug Metabolism and Disposition

AI-extracted · unverified · confirm at source

CYP2D6 is the primary enzyme catalysing ibogaine O-demethylation to noribogaine (KMapp 1.1 µM, IC₅₀ quinidine 0.2 µM, r²=0.711 with bufuralol 1'-hydroxylase). Poor metabolisers lack this activity.