Pharmacological comparison of the effect of ibogaine and 18-methoxycoronaridine on isolated smooth muscle from the rat and guinea-pig

Mundey, M. K., Blaylock, N. A., Mason, R., Glick, Stanley D., Maisonneuve, Isabelle M., Wilson, V. G. · 2000 · British Journal of Pharmacology

AI-extracted · unverified · confirm at source

PERIPHERAL: No evidence for µ-opioid receptor activity - naloxone-insensitive inhibition of ileum contractions. Novel finding: both agents enhance purinergic contractions 3-5 fold. Ibogaine enhances portal vein contractions; 18-MC does not.

Dosing: 1–30 µM ibogaine or 18-MC (isolated tissue) (not-specified)