Ibogaine neurotoxicity: a re-evaluation
Mechanisms Preclinical moderate
AI-extracted · unverified · confirm at source
40 mg/kg ibogaine (anti-addictive dose) produced no cerebellar Purkinje cell degeneration in rats; only high doses (≥100 mg/kg) caused degeneration, confined to lobules 5-7 and simplex. Anti-addictive and neurotoxic properties are dissociable.