Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes

Mash, Deborah C., Duque, Linda, Page, Bryan, Allen-Ferdinand, Kathleen · 2018 · Frontiers in Pharmacology

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Major cohort study: n=191 opioid/cocaine dependent patients (St. Kitts clinic). Ibogaine (8–12 mg/kg) effectively blocked withdrawal symptoms, reduced drug craving, improved mood. Safe in dose range studied with medical monitoring.

Dosing: 8–12 mg/kg ibogaine HCl (500–1000 mg absolute) (oral)

Sample size: 191

Safety data present: QTC

Contraindications: History of stroke, Epilepsy, Axis I psychotic disorders, Cardiovascular pathology, Liver pathology, HIV/AIDS, Bradycardic heart rate below 50 bpm, Long QT syndrome