Oral noribogaine shows high brain uptake and anti-withdrawal effects not associated with place preference in rodents

Mash, Deborah C., Ameer, Barbara, Prou, Delphine, Howes, John F., Maillet, Emeline L. · 2016 · Journal of Psychopharmacology

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Oral noribogaine reduced morphine withdrawal 88% (ED50=13mg/kg), brain/blood ratio 7±1, no conditioned place preference. Metabolite mediates ibogaine's anti-withdrawal effects.

Dosing: 10–100 mg/kg oral noribogaine (mouse/rat) (oral)