Ibogaine in the Treatment of Heroin Withdrawal

Mash, Deborah C., Kovera, Craig A., Pablo, John, Tyndale, Rachel, Ervin, Frank R., Kamlet, Jeffrey D., Hearn, W. Lee · 2001 · The Alkaloids: Chemistry and Biology

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PHARMACOKINETICS: Ibogaine peaks ~1h (3.2±1.3 µg/mL at 8-12mg/kg), T½ 7.3±3.2h. Noribogaine appears within 2h, persists 24-48+ hours. CYP2D6 polymorphisms affect metabolism. Establishes dose-PK relationships.

Dosing: 800 mg (10 mg/kg) ibogaine HCl fixed dose (n=32 cohort); broader Mash programme used 8, 10, or 12 mg/kg across >150 subjects (oral)

Sample size: 32

Safety data present: QTC