Medication Development of Ibogaine as a Pharmacotherapy for Drug Dependence

Mash, Deborah C., Kovera, Craig A., Buck, Billy E., Norenberg, Michael D., Shapshak, Paul, Hearn, W. Lee, Sanchez-Ramos, Juan · 1998 · Annals of the New York Academy of Sciences

AI-extracted · unverified · confirm at source

First human PK data: ibogaine peaks ~4 hr (600–1250 ng/ml), noribogaine persists >24 hr (~800 ng/ml). Identified noribogaine as active metabolite with μ-opioid partial agonist activity (Ki ~200 nM). 30 subjects, no significant AEs at 500–800 mg.

Sample size: 30