Identification of a Primary Metabolite of Ibogaine That Targets Serotonin Transporters and Elevates Serotonin

Mash, Deborah C., Staley, Julie K., Baumann, Michael H., Rothman, Richard B., Hearn, W. Lee · 1995 · Life Sciences

AI-extracted · unverified · confirm at source

First identification of noribogaine (12-hydroxyibogamine) as ibogaine's primary metabolite; Kᵢ 40.7 nM at SERT (10-fold > ibogaine); 3-fold 5-HT elevation in nucleus accumbens; long half-life with 508–706 ng/ml at 24h post-dose

Sample size: 3