Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

Marton, Soledad, González, Bruno, Rodríguez-Bottero, Sebastián, Miquel, Ernesto, Martínez-Palma, Laura, Pazos, Mariana, Prieto, José Pedro, Rodríguez, Paola, Sames, Dalibor, Seoane, Gustavo, Scorza, Cecilia, Cassina, Patricia, Carrera, Ignacio · 2019 · Frontiers in Pharmacology

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GDNF/BDNF MECHANISM: Ibogaine 40mg/kg upregulates GDNF in VTA (24h), BDNF in NAcc/SN/PFC. Dose-dependent, region-specific neurotrophin expression - mechanistic basis for lasting anti-addictive effects.

Dosing: 20–40 mg/kg i.p. ibogaine (rat) (intraperitoneal)