Attenuation of the reinforcing efficacy of morphine by 18-methoxycoronaridine
Mechanisms Preclinical moderate
AI-extracted · unverified · confirm at source
18-MC (40 mg/kg, 19 h pre) inhibits morphine-induced NAc dopamine release while enhancing metabolites. Downward shift in morphine dose–response — reduces reinforcing efficacy without altering potency.
Dosing: 40 mg/kg 18-MC (rat i.p./p.o.) (intraperitoneal)