Time-dependent interactions between iboga agents and cocaine

Maisonneuve, Isabelle M., Visker, Kathleen E., Mann, Gina L., Bandarage, Upul K., Kuehne, Martin E., Glick, Stanley D. · 1997 · European Journal of Pharmacology

AI-extracted · unverified · confirm at source

BIPHASIC TIMING: All iboga agents (ibogaine, noribogaine, 18-MC) inhibit cocaine hyperactivity at 1h but potentiate it at 19h post-administration. Explains divergent literature findings.

Dosing: 40 mg/kg ibogaine, noribogaine, or 18-MC (rat i.p.) (intraperitoneal)