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Interactions between ibogaine, a potential anti-addictive agent, and morphine: an in vivo microdialysis study

Maisonneuve, I. M., Keller, R. W. Jr., Glick, S. D. · 1991 · European Journal of Pharmacology

Mechanisms Preclinical high

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First in vivo microdialysis of ibogaine–morphine DA interactions. Ibogaine decreased striatal DA, increased prefrontal DA, and blocked morphine-induced DA rise 19 h post-dose across three brain regions.

Dosing: 40 mg/kg (rat, i.p.) (intraperitoneal)

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