Psychedelics Promote Structural and Functional Neural Plasticity

Ly, Calvin, Greb, Alexandra C., Cameron, Lindsay P., Wong, Jonathan M., Barragan, Eden V., Wilson, Paige C., Burbach, Kyle F., Soltanzadeh Zarandi, Sina, Sood, Alexander, Paddy, Michael R., Duim, Whitney C., Dennis, Megan Y., McAllister, A. Kimberley, Ori-McKenney, Kassandra M., Gray, John A., Olson, David E. · 2018 · Cell Reports

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LSD, DMT, psilocin, noribogaine promote neuritogenesis, spinogenesis, synaptogenesis via TrkB/mTOR/5-HT₂A. LSD EC₅₀=0.41nM. Ibogaine inactive; noribogaine active. Effects comparable to ketamine.