Serotonergic Psychedelics in Neural Plasticity

Lukasiewicz, Kacper, Baker, Jacob J., Zuo, Yi, Lu, Ju · 2021 · Frontiers in Molecular Neuroscience

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Noribogaine, not ibogaine, increases dendritic arbor complexity via 5-HT2A. Ibogaine neurotoxic at ≥50 mg/kg (Purkinje cell degeneration). TBG: non-hallucinogenic, non-cardiotoxic ibogaine analogue promoting spine formation.