Magnesium–ibogaine therapy effects on cortical oscillations and neural complexity in veterans with traumatic brain injury

Lissemore, Jennifer I., Chaiken, Anna, Cherian, Kirsten N., Buchanan, Derrick, Espil, Flint, Keynan, Jackob N., Sridhar, Malvika, Rolle, Camarin E., Saggar, Manish, Keller, Corey J., Williams, Nolan R. · 2025 · Nature Mental Health

AI-extracted · unverified · confirm at source

EEG shows theta-alpha power increase (d=0.45–0.61), beta-gamma decrease (d=0.50–0.73), reduced neural complexity and PAF (d=1.05) post-MISTIC; PAF and LZc reductions persist at 1 month; theta/beta ratio correlates with cognitive inhibition gains.

Dosing: 12.1 ± 1.2 mg/kg oral (ibogaine HCl) + IV magnesium sulfate (oral)

Sample size: 30

Safety data present: ELECTROLYTE

Contraindications: Concurrent psychiatric medications (required discontinuation prior to treatment), Concurrent benzodiazepine use (required discontinuation prior to treatment), Medications with potential drug–drug interactions