Psilocybin and Ibogaine as Therapeutic Candidates for Cocaine Addiction: Insights from a Rat Self-Administration Model

Koutrouli, I. R. A., Šíchová, K., Kacper, W., Brejtr, V., Aleksić, K., Miniariková, N., Lhotková, E., Nikolič, M., Páleníček, T. · 2026 · Neuroscience Applied

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Rat IVSA: ibogaine (10 + 40 mg/kg) and psilocybin reduced cocaine-seeking and facilitated extinction. Novel two-dose protocol. No reinstatement effects.

Dosing: ibogaine 10 + 40 mg/kg i.p.; psilocybin 1.25 + 5 mg/kg i.p. (intraperitoneal)