Simultaneous quantification of ibogaine and noribogaine in human plasma and whole blood by liquid chromatography with electrospray ionization mass spectrometric detection

Kontrimavičiūtė, Vilma, Breton, Hervé, Mathieu, Olivier, Mathieu-Daudé, Jean Claude, Bressolle, Françoise M.M. · 2006 · Journal of Chromatography B

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First validated LC-ESI-MS method for ibogaine/noribogaine in plasma (LLOQ 0.89/1 µg/L) and whole blood (LLOQ 1.78/2 µg/kg). Fatal poisoning case: blood levels 10.8 µg/g ibogaine, 20.8 µg/g noribogaine (10–20× therapeutic).