Streamlined screening platforms lead to the discovery of pachysiphine synthase from Tabernanthe iboga

Kamileen, Mohamed O., Nakamura, Yoko, Luck, Katrin, Heinicke, Sarah, Hong, Benke, Colinas, Maite, Lichman, Benjamin R., O'Connor, Sarah E. · 2024 · bioRxiv (preprint)

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Discovery of two T. iboga CYP450 enzymes: pachysiphine synthase (TiPS) and tabersonine-16-hydroxylase (TiT16H) using N. benthamiana leaf disk screening; advances understanding of MIA biosynthesis