Efficient and modular synthesis of ibogaine and related alkaloids

Iyer, Rishab N., Favela, David, Domokos, Andras, Zhang, Guoliang, Avanes, Arabo A., Carter, Samuel J., Basargin, Andrian G., Davis, Alexis R., Tantillo, Dean J., Olson, David E. · 2025 · Nature Chemistry

AI-extracted · unverified · confirm at source

Gram-scale 7-step ibogaine synthesis from pyridine (Olson lab). Enables analogue production. Unnatural (+)-ibogaine lacks psychoplastogenic effects. (-)-10-fluoroibogamine shows exceptional neuroplasticity and SERT modulation.