The Nonclassic Psychedelic Ibogaine Disrupts Cognitive Maps

Ivan, Victorita E., Tomàs-Cuesta, David P., Esteves, Ingrid M., Curic, Davor, Mohajerani, Majid, McNaughton, Bruce L., Davidsen, Joern, Gruber, Aaron J. · 2024 · Biological Psychiatry: Global Open Science

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Two-photon microscopy: ibogaine (40mg/kg) destabilised cognitive map in retrosplenial cortex. Supports entropy hypothesis - psychedelics disrupt constraining representations, increasing neural signalling entropy.