Deciphering Ibogaine's Matrix Pharmacology: Multiple Transporter Modulation at Serotonin Synapses
Hwu, Christopher, Havel, Václav, Westergaard, Xavier, Mendieta, Adriana M., Serrano, Inis C., Hwu, Jennifer, Walther, Donna, Lankri, David, Selinger, Tim Luca, He, Keer, Liu, Rose, Shern, Tyler P., Sun, Steven, Ma, Boxuan, González, Bruno, Rodriguez, Luisina, Goodman, Hannah J., Wu, Hunter, Sonders, Mark S., Baumann, Michael H., Carrera, Ignacio, Sulzer, David, Sames, Dalibor · 2025 · Journal of the American Chemical Society
Mechanisms In vitro high
AI-extracted · unverified · confirm at source
Defines 'matrix pharmacology' - ibogaine/noribogaine modulate VMAT2 (sub-µM), SERT, OCT2 simultaneously. Dual VMAT2+SERT inhibition explains neurochemical effects. Not substrate-type releasers. No catalepsy unlike other VMAT2 inhibitors.