Disrupting Substance Use Disorder: The Chemistry of Iboga Alkaloids

Hughes, Alexander J., Hamelink, Charles R., Townsend, Steven D. · 2024 · European Journal of Organic Chemistry

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Comprehensive synthesis review: 20+ total syntheses of iboga alkaloids. Drug leads 18-MC (Phase II), oxa-noribogaine (κ-opioid, no cardiac risk), TBG (non-hallucinogenic, 5-HT2A plasticity)

Safety data present: HERG