Combating Substance Abuse with Ibogaine: Pre- and Posttreatment Recommendations and an Example of Successive Model Fitting Analyses

Hittner, James B., Quello, Susan B. · 2004 · Journal of Psychoactive Drugs

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Dose-to-weight ratio predicts heroin abstinence (sigmoidal R²=.88); threshold ~16 mg/kg; pre/posttreatment psychosocial recommendations proposed

Dosing: 700–1800 mg oral ibogaine HCl (11.7–25.0 mg/kg DWR); test dose 100–200 mg; threshold ~16 mg/kg (oral)

Contraindications: Active psychosis or psychosis-prone individuals (schizophrenia, bipolar disorder)