Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine
Mechanisms In vitro high
AI-extracted · unverified · confirm at source
FOUNDATIONAL: First demonstration that ibogaine upregulates GDNF via autoregulatory feedback loop. 10µM ibogaine induces sustained GDNF mRNA increase (48h+). GDNF positively regulates own expression - mechanism for long-term anti-addiction effects.
Dosing: 10 µM ibogaine HCl in cell culture (not-applicable)