Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-addiction Drug Ibogaine against Alcohol Consumption

He, Dao-Yao, McGough, Nancy N. H., Ravindranathan, Ajay, Jeanblanc, Jerome, Logrip, Marian L., Phamluong, Khanhky, Janak, Patricia H., Ron, Dorit · 2005 · The Journal of Neuroscience

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Ibogaine reduces ethanol self-admin via VTA GDNF upregulation. Intra-VTA GDNF mimics effect; anti-GDNF antibodies attenuate it (79% vs 39% reduction). No neurotoxicity at 40 mg/kg.